Oral Anticoagulant and Antiplatelet Therapy for Peripheral Arterial Disease: A Meta-Analysis of Randomized Controlled Trials

A retrospective review of PubMed, Embase, Web Science, and Cochrane Library for randomized controlled trials was performed from January 1, 1990 to June 2020. Based on three patients with peripheral arterial disease (PAD), oral anticoagulant plus antiplatelet therapy significantly improved acute limb ischemia, stroke, major amputation events compared agents alone. However, not effective the prevention myocardial infarction or death any cause. Additionally, a significant increase in bleeding demonstrated. This meta-analysis showed that PAD can improve ischemia stroke risk alone but does decrease might events.